MK677

MK677 (Ibutamoren) - 10mg/ml. (30ml bottle)

MK-677 is a non-peptide, orally active compound that functions as a possible growth hormone secretagogue by interacting with the ghrelin receptor. It is being investigated for its potential to stimulate endogenous growth hormone and IGF-1 release through natural signaling pathways. Due to its non-peptide structure, it has been of interest in long-term endocrine and metabolic research models

MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue that functions as a high-affinity agonist of the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary. Activation of GHS-R1a stimulates growth hormone (GH) release via phospholipase C–IP₃/Ca²⁺ signaling, increasing pulsatile GH secretion without suppressing endogenous rhythm. Elevated GH subsequently induces hepatic and peripheral production of insulin-like growth factor-1 (IGF-1), mediating downstream effects on protein synthesis, nitrogen retention, lipolysis, and bone metabolism, while largely bypassing direct androgen or estrogen receptor pathways.

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