Topical: RU58841 + Minoxidil

*Please store product in fridge and apply 25-35 minutes post shower.

RU58841 and Minoxidil are both compounds used in the treatment of hair loss, but they work through different mechanisms:

RU58841: A topical anti-androgen that blocks DHT (dihydrotestosterone) receptors in the scalp, preventing DHT from binding to hair follicles, which is a key factor in androgenic alopecia (male and female pattern baldness). It helps reduce hair follicle miniaturization and promotes hair growth.

Minoxidil: A vasodilator that increases blood flow to the scalp, stimulating hair follicles and promoting hair growth. Its exact mechanism isn’t fully understood, but it’s believed to extend the anagen (growth) phase of hair follicles and increase follicle size.

Both are effective for promoting hair regrowth but target different aspects of hair loss: RU58841 targets hormonal factors, while Minoxidil improves scalp circulation and follicle health.

RU58841 is a topical anti-androgen that selectively inhibits the binding of dihydrotestosterone (DHT) to androgen receptors on hair follicle cells. By blocking DHT at the receptor level, it prevents DHT-mediated follicular miniaturization and prolongs the anagen (growth) phase of hair follicles, mitigating androgenic alopecia.

Minoxidil, a potassium channel opener, enhances vasodilation and increases blood flow to the scalp, leading to improved oxygen, nutrient, and growth factor delivery to hair follicles. It stimulates prolongation of the anagen phase and induces follicular regeneration, likely via activation of VEGF and PDGF pathways, although its exact mechanism remains incompletely understood.

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