RAD-140

RAD140: 10mg/ml. (Testolone)

RAD-140 is a selective androgen receptor modulator (SARM) developed for research purposes. It is being investigated for its potential to selectively bind to androgen receptors in certain tissues while exhibiting reduced activity in others. Research interest focuses on its receptor selectivity, signaling behavior, and tissue-specific interactions.

RAD140 (testolone) is a nonsteroidal selective androgen receptor modulator (SARM) that functions as a high-affinity agonist of the androgen receptor (AR), inducing ligand-dependent conformational changes that promote tissue-selective coactivator recruitment and gene transcription. It preferentially activates anabolic AR signaling pathways in skeletal muscle and osteoblasts, upregulating myogenic and osteogenic gene expression, while exhibiting functional antagonism or reduced agonism in prostate and mammary tissues. RAD140 is not a substrate for aromatase or 5α-reductase, thereby avoiding conversion to estrogenic or dihydrotestosterone (DHT) metabolites, and exerts downstream effects through modulation of protein synthesis, nitrogen retention, and bone mineralization.

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