GHK-CU

GHK-Cu (Glycyl-L-Histidyl-L-Copper) is a naturally occurring copper peptide found in human plasma, saliva, and urine. It functions as a signaling molecule and is being researched for its potential role in supporting normal tissue remodeling and repair processes. GHK-Cu is being investigated for its potential involvement in pathways related to collagen and elastin, two key structural proteins that help maintain skin strength, firmness, and elasticity. Research explores how GHK-Cu may influence cellular activity associated with extracellular matrix balance and antioxidant defense, which could contribute to overall skin structure and appearance.

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a tripeptide naturally bound to copper ions that functions as a regenerative and wound-healing modulator. It promotes cell proliferation, migration, and differentiation in fibroblasts, keratinocytes, and endothelial cells, supporting tissue repair, angiogenesis, and extracellular matrix remodeling. GHK-Cu upregulates collagen, elastin, and glycosaminoglycan synthesis while downregulating matrix metalloproteinases (MMPs) that degrade the extracellular matrix. It also exhibits antioxidant, anti-inflammatory, and DNA repair–enhancing properties, stabilizing genomic integrity and reducing oxidative stress. Through these mechanisms, GHK-Cu contributes to skin rejuvenation, wound healing, and overall tissue regeneration.

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