Enclomiphene Citrate

Enclomiphene Citrate: 20mg/ml (30ml)

Enclomiphene is a non-steroidal compound and an isomer of clomiphene citrate. It is being investigated for its potential role in hormonal feedback mechanisms and endocrine signaling pathways. Research interest centers on its interaction with estrogen receptors and its influence on upstream hormone regulation such as potential to stimulate LH and FSH

Enclomiphene citrate is a nonsteroidal selective estrogen receptor modulator (SERM) that acts primarily as an estrogen receptor (ER) antagonist in the hypothalamus and pituitary. By competitively inhibiting estradiol-mediated negative feedback at ERα, it increases gonadotropin-releasing hormone (GnRH) pulsatility, leading to elevated secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. This upregulation stimulates Leydig cell steroidogenesis and Sertoli cell function, resulting in increased endogenous testosterone production and spermatogenesis without direct androgen receptor activation.

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