{"product_id":"tak653","title":"TAK653","description":"\u003cp\u003e\u003cstrong\u003eTAK653 - 15ml (4mg\/ml)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudied for its role in:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInvestigated for its ability to Enhance AMPA receptor signalling – Investigational positive allosteric modulator (PAM) of AMPA receptors, promoting glutamatergic neurotransmission without directly activating the receptor.\u003cspan class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003ePromotes synaptic plasticity – Preclinical studies suggest enhancement of long-term potentiation (LTP), a key neurophysiological mechanism underlying learning and memory.\u003c\/li\u003e\n\u003cli\u003eIncreases BDNF signalling – Demonstrated to elevate brain-derived neurotrophic factor (BDNF) expression and downstream TrkB-mediated neuroplasticity pathways in experimental models.\u003c\/li\u003e\n\u003cli\u003eSupports cognitive function – Investigated for improving learning, memory consolidation, executive function, and attentional performance in preclinical cognitive paradigms.\u003c\/li\u003e\n\u003cli\u003ePotential antidepressant activity – Research indicates rapid and sustained antidepressant-like effects, potentially mediated through AMPA-dependent activation of BDNF\/mTOR signalling cascades.\u003c\/li\u003e\n\u003cli\u003eNeuroprotective potential – Experimental evidence suggests support for neuronal resilience and synaptic integrity through modulation of neurotrophic signalling and adaptive synaptic remodeling.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Pinnacle Research Labs","offers":[{"title":"Default Title","offer_id":67388397912368,"sku":null,"price":70.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0946\/0547\/6144\/files\/tak653download_e10ce40a-56cb-4cb9-8474-86b01de29a32.png?v=1785831663","url":"https:\/\/pinnacleresearchlabs.com.au\/products\/tak653","provider":"Pinnacle Research Labs","version":"1.0","type":"link"}